Lung tumorigenesis associated with erb-B-2 and erb-B-3 overexpression in human erb-B-3 transgenic mice is enhanced by methylnitrosourea

Transcription Activation by the Human Estrogen Receptor Subtype b (ERb) Studied with ERb and ERa Receptor Chimeras*

We have studied the two estrogen receptor (ER) subtypes, ERa and ERb, and chimeric constructs with ERa and ERb to examine the bioactivities of these receptors and their responses to estrogen and antiestrogen ligands. Transcriptional activity of ERb is highly dependent on cell/promoter context and on the nature of the ligand. ERb activated significant levels of transcription in response to estro...

[The relationship between p53 protein and c-erb B-2 expression and apoptosis in colorectal cancer].

In order to elucidate the relationship between tumor growth and various kinds of gene expression and the occurrence of apoptosis in the front portion of neoplastic invasion, 57 advanced colorectal cancers were studied by immunohistochemical staining of p53, c-erb B-2, the TUNEL method and electron microscopy. Light microscopically, the columnar epithelial cells of adenocarcinoma frequently show...

Regulation of circadian behaviour and metabolism by REV-ERB-α and REV-ERB-β

The circadian clock acts at the genomic level to coordinate internal behavioural and physiological rhythms via the CLOCK–BMAL1 transcriptional heterodimer. Although the nuclear receptors REV-ERB-a and REV-ERB-b have been proposed to form an accessory feedback loop that contributes to clock function, their precise roles and importance remain unresolved. To establish their regulatory potential, w...

Progressive Muscular Dystrophy (Erb.)

ERB-1094.fm

The evaluative character of a word is called its semantic orientation. A positive semantic orientation implies desirability (e.g., “honest”, “intrepid”) and a negative semantic orientation implies undesirability (e.g., “disturbing”, “superfluous”). This paper introduces a simple algorithm for unsupervised learning of semantic orientation from extremely large corpora. The method involves issuing...